Latest publications

2022

Heering J, Hernandez-Olmos V, Ildefeld N, Liu T, Kaiser A, Naeem Z, Frömel T, Fleming I, Steinhilber D, Proschak E (2022) J Med Chem. 65, 3, 2023–2034. doi:  10.1021/acs.jmedchem.1c01589

Vellecco V, Panza E, Bibli SI, Casillo GM, Raucci F, Smimmo M, Villani R, Cavezza MR, Fleming I, d’Emmanuele di Villa Bianca R, Maione F, Cirino G, Bucci M (2022) Phosphodiesterase S-sulfhydration contributes to anomalous skeletal muscle contraction. Pharmacol Res. 177:106108. doi: 10.1016/j.phrs.2022.106108

Elwakeel E, Brüggemann M, Wagih J, Litagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten F, Zarnack K, Brüne B, Weigert A (2022). Disrupting prostaglandin E2 signaling in cancer-associated fibroblasts limits mammary carcinoma growth but promotes metastasis. Cancer Res. canres.2116.2021. doi: 10.1158/0008-5472.CAN-21-2116

Frömel T, Naeem Z, Pirzeh L, Fleming I (2021). Cytochrome P450-derived lipid mediators in angiogenesis and stem cell biology. Pharmacol Ther. 108049. doi: 10.1016/j.pharmthera.2021.108049


2021

Fischer C, Willken-Schmitz A, Hernandez-Olmos V, Proschak E, Stark H, Fleming I, Weigert A, Thurn M, Hofmann M, Werner ER, Geisslinger G, Niederberger E, Watschinger K, Tegeder I (2021). AGMO inhibitor reduces 3T3-L1 adipogenesis. Cells. 10:1081. doi:  10.3390/cells10051081

Kesavan R, Frömel T, Zukunft S, Brüne B, Weigert A, Wittig I, Popp R, Fleming I (2021). The consequences of soluble epoxide hydrolase deletion on tumorigenesis and metastasis in a mouse model of breast cancer. Int J Mol Sci. 22:7120. doi:  10.3390/ijms22137120

Hu J, Brecht R, Sisignano M, Angioni C, Bibli I-S, Perumal N, Fisslthaler B, Kleinert H, Gericke A, Pfeiffer N, Fleming I, Marnicam C (2021). Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicits vasoconstriction of the murine ophthalmic artery. Sci Rep. I11(1):18764. doi:  10.1038/s41598-021-98236-w

Wagner JUG, Bojkova D, Shumliakivska M, Luxán G, Nicin L, Aslan GS, Milting H, Kandler JD, Dendorfer A, Heumueller AW, Fleming I, Bibli S-I, Jakobi T, Dieterich C, Zeiher AM, Ciesek S, Cinatl J, Dimmeler S (2021). Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants. Basic Res Cardiol. 116:42. doi:  10.1007/s00395-021-00882-8

Chen Y, Lin J, Schlotterer A, Kurowski L, Hoffmann S, Hammad S, Dooley S, Buchholz M, Hu J, Fleming I, Hammes HP (2021). miRNA-124 alleviates retinal vasoregression via regulating microglial polarization. Int J Mol Sci. 22:11068. doi:  10.3390/ijms222011068

Gurusamy M, Tischner D, Shao J, Klatt S, Zukunft S, Bonnavion R, Günther S, Siebenbrodt K, Kestner R-I, Kuhlmann T, Fleming I, Offermanns S, Wettschureck N (2021). G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Nat Commun. 12:6798. doi:  10.1038/s41467-021-26882-9

Bibli S-I, Fleming I (2021). Oxidative post translational modifications: a focus on cysteine S-sulfhydration and the regulation of endothelial fitness. Antioxid Redox Signal 35:1494-1514. doi:  10.1089/ars.2021.0162

Fleming I (2021). Who’s afraid of being a reviewer? An A-Z of tips and tricks for peer review. CVR Onlife. 117(8):e104-e105. doi: 10.1093/cvr/cvab180

Tsilimigras DI, Bibli S-I, Siasos G, Oikonomou E, Perrea DN, Filis K, Tousoulis D, Sigala F (2021). Regulation of long non-coding RNAs by statins in atherosclerosis. Biomolecules. 11:623. doi:  10.3390/biom11050623.

Mukherjee S, Perez KA, Lago LC, Klatt S, McLean CA, Birchall IE, Barnham KJ, Masters CL, Roberts BR (2021). Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease. Brain Commun. 3:fcab028. doi: 10.1093/braincomms/fcab028

Klatt S, Doecke JD, Roberts A, Boughton BA, Masters CL, Horne M, Roberts BR (2021). A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease. NPJ Parkinsons Dis. 7:94. doi: 10.1038/s41531-021-00239-x

Siragusa M, Justo AFO, Malacarne PF, Strano A, Buch A, Withers B, Peters KG, Fleming I (2021). VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes. Cardiovasc Res:cvaa213. doi: 10.1093/cvr/cvaa213

Fleming I (2021). A prickly situation: competitive antagonism by different hedgehog proteins. Cardiovascular Research: cvab037. doi: 10.1093/cvr/cvab037

Wang B, Wu L, Chen J, Dong L, Chen C, Wen Z, Hu J, Fleming I, Wang DW (2021). Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduct Target Ther 6 (1):94. doi: 10.1038/s41392-020-00443-w

Hartmann M, Bibli SI, Tews D, Ni X, Kircher T, Kramer JS, Kilu W, Heering J, Hernandez-Olmos V, Weizel L, Scriba GKE, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P, Proschak E (2021). Combined cardioprotective and adipocyte browning effects promoted by the eutomer of dual sEH/PPARγ modulator. J Med Chem 64:2851-2828. doi: 10.1021/acs.jmedchem.0c02063

Huang J, Covic M, Huth C, Rommel M, Adam J, Zukunft S, Prehn C, Wang L, Nano J, Scheerer MF, Neschen S, Kastenmüller G, Gieger C, Laxy M, Schliess F, Adamski J, Suhre K, de Angelis MH, Peters A, Wang-Sattler R (2021). Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse. Metabolites 11 (2):89. doi: 10.3390/metabo11020089

Delgado Lagos FA, Elgheznawy A, Kyselova A, Meyer Zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, Fleming I (2021). Secreted modular calcium binding protein 1 binds/activates thrombin to account for platelet hyper-reactivity in diabetes. Blood 137 (12):1641-1651. doi: 10.1182/blood.2020009405

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S (2021). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun 12 (1):681. doi: 10.1038/s41467-021-20905-1

Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I, Benz PM (2021). EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep 22 (2):e48961. doi: 10.15252/embr.201948961

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I (2021). Mapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function. Circulation 143 (9):935-948. doi: 10.1161/CIRCULATIONAHA.120.051877

Kashefiolasl S, Leisegang MS, Helfinger V, Schürmann C, Pflüger-Müller B, Randriamboavonjy V, Vasconez AE, Carmeliet G, Badenhoop K, Hintereder G, Seifert V, Schröder K, Konczalla J, Brandes RP (2021). Vitamin D – a new perspective in treatment of cerebral vasospasm. Neurosurgery 88 (3):674-685. doi: 10.1093/neuros/nyaa484

Kyselova A, Zukunft S, Puppe D, Wittig I, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V (2021). Human platelets are a source of collagen I. Haematologica 106 (3):899-902. doi: 10.3324/haematol.2020.255612

Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmidt T, Fleming I, Fulda S, Weigert A (2021). Apoptotic cells induce proliferation of peritoneal macrophages. Int J Mol Sci. 22:2230. doi: 10.3390/ijms22052230


2020

Kyselova A, Elgheznawy A, Wittig I, Heidler J, Mann AW, Ruf W, Fleming I, Randriamboavonjy V (2020). Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes. Basic Res Cardiol 115 (6):75. doi: 10.1007/s00395-020-00833-9

Mamazhakypov A, Weiß A, Zukunft S, Sydykov A, Kojonazarov B, Wilhelm J, Vroom C, Petrovic A, Kosanovic D, Weissmann N, Seeger W, Fleming I, Iglarz M, Grimminger F, Ghofrani HA, Pullamsetti SS, Schermuly RT (2020). Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats. Pulm Circ 10 (4):2045894020947283. doi: 10.1177/2045894020947283

Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I, Randriamboavonjy V (2020). Cyclin y is expressed in platelets and modulates integrin outside-in signaling. Int J Mol Sci 21 (21):8239. doi: 10.3390/ijms21218239

Huang J, Huth C, Covic M, Troll M, Adam J, Zukunft S, Prehn C, Wang L, Nano J, Scheerer MF, Neschen S, Kastenmüller G, Suhre K, Laxy M, Schliess F, Gieger C, Adamski J, Hrabe de Angelis M, Peters A, Wang-Sattler R (2020). Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes. Diabetes 69 (12):2756-2765. doi: 10.2337/db20-0586

Lin J, Hu J, Schlotterer A, Wang J, Kolibabka M, Awwad K, Dietrich N, Breitschopf K, Wohlfart P, Kannt A, Lorenz K, Feng Y, Popp R, Hoffmann S, Fleming I, Hammes HP (2020). Protective effect of soluble epoxide hydrolase inhibition in retinal vasculopathy associated with polycystic kidney disease. Theranostics 10 (17):7857-7871. doi: 10.7150/thno.43154

Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S (2020). Adipocyte piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun 11 (1):2303. doi: 10.1038/s41467-020-16026-w

Kesavan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I (2020). Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer. Proc Natl Acad Sci U S A 117 (11):5923-5930. doi: 10.1073/pnas.1921381117

Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A (2020). Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. Biochem Pharmacol 176 :113833. doi: 10.1016/j.bcp.2020.113833

Dos Santos LRB, Fleming I (2020). Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome. Prostaglandins Other Lipid Mediat 148 :106407. doi: 10.1016/j.prostaglandins.2019.106407

Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming I (2020). Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation. Redox Biol 28 :101379. doi: 10.1016/j.redox.2019.101379

Benz PM, Ding Y, Stingl H, Loot AE, Zink J, Wittig I, Popp R, Fleming I (2020). AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting. Acta Physiol (Oxf) 228 (1):e13325. doi: 10.1111/apha.13325

Vellecco V, Martelli A, Bibli IS, Vallifuoco M, Manzo OL, Panza E, Citi V, Calderone V, de Dominicis G, Cozzolino C, Basso EM, Mariniello M, Fleming I, Mancini A, Bucci M, Cirino G (2020). Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. Br J Pharmacol 177 (4):810-823. doi: 10.1111/bph.14700

Govar AA , Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos S, Módis K (2020). 3‐Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. Br J Pharmacol. 177(4): 866–883. doi: 10.1111/bph.14574 .

Garcia V, Park EJ, Siragusa M, Frohlich F, Haque MM, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, and Sessa WC (2020). Unbiased proteomics identifies plasminogen activatorinhibitor-1 as a negative regulator of endothelial nitricoxide synthase. PNAS 117 (17) 9497-9507; doi: 10.1073/pnas.1918761117


2019

Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR (2019). Coronary revascularization during heart regeneration is regulated by epicardial and endocardial cues and forms a scaffold for cardiomyocyte repopulation. Dev Cell 51 (4):503-515.e4. doi: 10.1016/j.devcel.2019.10.019

Fink AF, Ciliberti G, Popp R, Sirait-Fischer E, Frank AC, Fleming I, Sekar D, Weigert A, Brüne B (2019). IL27Rα deficiency alters endothelial cell function and subverts tumor angiogenesis in mammary carcinoma. Front Oncol 9 :1022. doi: 10.3389/fonc.2019.01022

Siuda D, Randriamboavonjy V, Fleming I (2019). Regulation of calpain 2 expression by miR-223 and miR-145. Biochim Biophys Acta Gene Regul Mech 1862 (10):194438. doi: 10.1016/j.bbagrm.2019.194438

Lasch M, Kleinert EC, Meister S, Kumaraswami K, Buchheim JI, Grantzow T, Lautz T, Salpisti S, Fischer S, Troidl K, Fleming I, Randi AM, Sperandio M, Preissner KT, Deindl E (2019). Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice. Blood 134 (17):1469-1479. doi: 10.1182/blood.2019001392

Hu J, Bibli SI, Wittig J, Zukunft S, Lin J, Hammes HP, Popp R, Fleming I (2019). Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity. J Clin Invest 129 (12):5204-5218. doi: 10.1172/JCI123835

Fleming I (2019) New lipid mediators in retinal angiogenesis and retinopathy. Front Pharmacol 10 :739. doi: 10.3389/fphar.2019.00739

Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I (2019). Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition. EMBO J 38 (17):e100938. doi: 10.15252/embj.2018100938

Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I (2019). Myeloid-specific deletion of the AMPKα2 subunit alters monocyte protein expression and atherogenesis. Int J Mol Sci 20 (12):. doi: 10.3390/ijms20123005

Leisegang MS, Bibli SI, Günther S, Pflüger-Müller B, Oo JA, Höper C, Seredinski S, Yekelchyk M, Schmitz-Rixen T, Schürmann C, Hu J, Looso M, Sigala F, Boon RA, Fleming I, Brandes RP (2019). Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS. Eur Heart J 40 (30):2523-2533. doi: 10.1093/eurheartj/ehz393

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S (2019). Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest 129 (7):2775-2791. doi: 10.1172/JCI123825

Mudersbach T, Siuda D, Kohlstedt K, Fleming I (2019). Epigenetic control of the angiotensin-converting enzyme in endothelial cells during inflammation. PLoS One 14 (5):e0216218. doi: 10.1371/journal.pone.0216218

Fuhrmann DC, Olesch C, Kurrl, N, Schnütgen F, Zukunft S, Fleming I, Brüne B (2019). Chronic hypoxia enhances β-oxidation-dependent electron transport via electron transferring flavoproteins. Cells 8 (2):172. doi: 10.3390/cells8020172

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H (2019). ADAR1 is required for dendritic cell subset homeostasis and alveolar macrophage function. J Immunol 202 (4):1099-1111. doi: 10.4049/jimmunol.1800269

Kyselova A, Hinrichsmeyer H, Zukunft S, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V (2019). Association between arginase-containing platelet-derived microparticles and altered plasma arginine metabolism in polycystic ovary syndrome. Metabolism 90 :16-19. doi: 10.1016/j.metabol.2018.10.008

Randriamboavonjy V, Kyselova A, Fleming I (2019). Redox-regulation of calpain and its consequence for vascular function. Antioxid Redox Signal 30 (7):1011-1026. doi: 10.1089/ars.2018.7607

Bibli SI, Papapetropoulos A, Iliodromitis EK, Daiber A, Randriamboavonjy V, Steve, S, Brouckaert P, Chatzianastasiou A, Kypreos KE, Hausenloy DJ, Fleming I, Andreadou I (2019). Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug. Cardiovasc Res 115 (3):625-636. doi: 10.1093/cvr/cvy222

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang MS (2019). The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3’UTR of soluble epoxide hydrolase. Acta Physiol (Oxf) 225 (1):e13168. doi: 10.1111/apha.13168

Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I (2019). Cystathionine γ lyase sulfhydrates the RNA binding protein human antigen R to preserve endothelial cell function and delay atherogenesis. Circulation 139 (1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757

Ullrich M, Assmus B, Augustin AM, Habich H, Abesser M, Martin MJ, Werner F, Erkens R, Arias-Loza AP, Umbenhauer S, Wagner H, Benz PM, Unger A, Linke WA, Frantz S, Baba HA, Kuhn M, Schuh K. (2019) SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy. J Mol Cell Cardiol 129:13-26 doi: 10.1016/j.yjmcc.2019.01.023

von Knethen A, Schafer A, Kuchler L, Knape T, Christen U, Hintermann E, Fisslthaler B, Schroder K, Brandes RP, Genz B, Abshagen K, Putzer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brune B. (2019). Tolerizing CTL by sustained hepatic PD-L1 expression provides a new therapy approach in mouse sepsis. Theranostics 9:2003-2016 doi: 10.7150/thno.28057


2018

Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, Brüne B (2018). Polarization of human macrophages by interleukin-4 does not require ATP-citrate lyase. Front Immunol 9 :2858. doi: 10.3389/fimmu.2018.02858

Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher T, Ebnet K, Potente M, Hirose T, Ohno S, Fleming I, Gattenlöhner S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M (2018). aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nat Commun 9 (1):5357. doi: 10.1038/s41467-018-07739-0

Zippel N, Loot AE, Stingl H, Randriamboavonjy V, Fleming, I, Fisslthaler, B (2018). Endothelial AMP-activated kinase α1 phosphorylates eNOS on Thr495 and decreases endothelial NO formation. Int J Mol Sci 19 (9):. doi: 10.3390/ijms19092753

Randriamboavonjy V, Fleming I (2018). Platelet communication with the vascular wall: role of platelet-derived microparticles and non-coding RNAs. Clin Sci (Lond) 132 (17):1875-1888. doi: 10.1042/CS20180580

Bibli SI, Luck B, Zukunft S, Wittig J, Chen W, Xian M, Papapetropoulos A, Hu J, Fleming I (2018). A selective and sensitive method for quantification of endogenous polysulfide production in biological samples. Redox Biol 18 :295-304. doi: 10.1016/j.redox.2018.07.016

Nicolay JP, Thorn V, Daniel C, Amann K, Siraskar B, Lang, F, Hillgruber C, Goerge T, Hoffmann S, Gorzelanny C, Huck V, Mess C, Obser T, Schneppenheim R, Fleming I, Schneider MF, Schneider SW (2018). Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy. Sci Rep 8 (1):10945. doi: 10.1038/s41598-018-28961-2

Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V (2018). Alpha-1 antitrypsin inhibits ATP-mediated release of interleukin-1β via CD36 and nicotinic acetylcholine receptors. Front Immunol 9 :877. doi: 10.3389/fimmu.2018.00877

Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann, C Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP (2018). Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nat Commun 9 (1):2292. doi: 10.1038/s41467-018-04602-0

Hu J, Frömel T, Fleming I (2018). Angiogenesis and vascular stability in eicosanoids and cancer. Cancer Metastasis Rev 37 (2-3):425-438. doi: 10.1007/s10555-018-9732-2

Cencioni C, Spallott, F, Savoia M, Kuenne C, Guenther S, Re A, Wingert S, Rehag, M, Sürün D, Siragusa M, Smith JG, Schnütgen F, von Melchner H, Rieger MA, Martelli F, Riccio A, Fleming I, Braun T, Zeiher AM, Farsetti A, Gaetano C (2018). Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells. Nat Commun 9 (1):1281. doi: 10.1038/s41467-018-03668-0

Kohlstedt K, Trouvain C, Frömel T, Mudersbach T, Henschler R, Fleming, I (2018). Role of the angiotensin-converting enzyme in the G-CSF-induced mobilization of progenitor cells. Basic Res Cardiol 113 (3):18. doi: 10.1007/s00395-018-0677-y

Laban H, Weigert A, Zink J, Elgheznawy A, Schürmann C, Günther L, Abdel Malik R, Bothur S, Wingert S, Bremer R, Rieger MA, Brüne B, Brandes RP, Fleming I, Benz PM (2018). VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia. J Cell Biol 217 (4):1503-1519. doi: 10.1083/jcb.201702048

Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D (2018). Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses. Biochim Biophys Acta Mol Cell Biol Lipids 1863 (4):433-446. doi: 10.1016/j.bbalip.2018.01.009

Zukunft S, Prehn C, Röhring C, Möller G, Hrabě de Angelis M, Adamski J, Tokarz J (2018). High-throughput extraction and quantification method for targeted metabolomics in murine tissues. Metabolomics 14 (1):18. doi: 10.1007/s11306-017-1312-x

Köhler D, Bibli SI, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja TF, Straub A, Benz PM, Rosenberger P (2018). Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning. Basic Res Cardiol 113 (2):11. doi: 10.1007/s00395-018-0667-0

Rezende F, Moll, F, Walter M, Helfinger V, Hahner F, Janetzko P, Ringel C, Weigert A, Fleming I, Weissmann N, Kuenne C, Looso M, Rieger MA, Nawroth P, Fleming T, Brandes RP, Schröder K (2018). The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice. Redox Biol 15 :12-21. doi: 10.1016/j.redox.2017.11.014

Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Kuenne C, Guenther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Sürün D, Schnütgen F, von Melchner H, Di Stilo A, Aragno M, Braspenning M, van Criekinge W, De Blasio MJ, Ritchie RH, Zaccagnini G, Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A, Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C (2018). Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from type2 diabetes patients: rescue by α-ketoglutarate and TET-TDG functional reactivation. Circ Res 122 (1):31-46. doi: 10.1161/CIRCRESAHA.117.311300

Elgheznawy A, Fleming I (2018). Platelet-enriched microRNAs and cardiovascular homeostasis. Antioxid Redox Signal 29 (9):902-921. doi: 10.1089/ars.2017.7289

Eresch J, Stumpf M, Koch A, Vutukuri R, Ferrrirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Hattenbach L-O, Pfeilschifter J, Pfeilschifter W (2018). Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Opthamol Vis Sci 59 (2):653-61. doi: 10.1167/iovs.17-22544

Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C (2018). Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells. Sci Rep 8:914. doi:  10.1038/s41598-018-19216-1

Glynos C, Bibli SI, Katsaounou P, Pavlidou A, Magkou C, Karavana V, Topouzis S, Kalomenidis I, Zakynthinos SG, Papapetropoulos A (2018). Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice. Am J Physiol Lung Cell Mol Physiol 315:L662-L672. doi: 10.1152/ajplung.00389.2017

Hansen JB, Dos Santos LRB, Liu Y, Prentice KJ, Teudt F, Tonnesen M, Jonas JC, Wheeler MB, Mandrup-Poulsen T (2018). Glucolipotoxic conditions induce beta-cell iron import, cytosolic ROS formation and apoptosis. J Mol Endocrinol 61:69-77. doi: 10.1530/JME-17-0262

Rebelato E, Santos LR, Carpinelli AR, Rorsman P, Abdulkader F (2018). Short-term high glucose culture potentiates pancreatic beta cell function. Sci Rep 8:13061. doi: 10.1038/s41598-018-31325-5

El-Battrawy I, Zhao Z, Lan H, Li X, Yucel G, Lang S, Sattler K, Schunemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, Muller OJ, Akin I (2018). Ion channel dysfunctions in dilated cardiomyopathy in limb-girdle muscular dystrophy. Circ Genom Precis Med 11:e001893. doi: 10.1161/CIRCGEN.117.001893


2017

Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mo, J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I (2017). Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature 552 (7684):248-252. doi: 10.1038/nature25013

Bibli SI, Szabo C, Chatzianastasiou A, Luck B, Zukunft S, Fleming I, Papapetropoulos A (2017). Hydrogen sulfide preserves eNOS function by inhibiting PYK2: implications for cardiomyocyte survival and cardioprotection. Mol Pharmacol 92 (6):718-730. doi: 10.1124/mol.117.109645

Ilina EI, Armento A, Sanchez LG, Reichlmeir M, Braun Y, Penski C, Capper D, Sahm F, Jennewein L, Harter PN, Zukunft S, Fleming I, Schulte D, Le Guerroué F, Behrends C, Ronellenfitsch MW, Naumann U, Mittelbronn M (2017). Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget 8 (40):67567-67591. doi: 10.18632/oncotarget.18747

Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, Frank AC, Scholich K, Pierre S, Syed SN, Olesch C, Ringleb J, Ören B, Döring C, Savai R, Jung M, von Knethen A, Levkau B, Fleming I, Weigert A, Brüne B (2017). S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β. J Exp Med 214 (9):2695-2713. doi: 10.1084/jem.20160392

Bibli SI, Zhou Z, Zukunft S, Fisslthaler B, Andreadou I, Szabo C, Brouckaert P, Fleming I, Papapetropoulos A (2017). Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischaemic insult: role of PYK2. Cardiovasc Res 113 (8):926-937. doi: 10.1093/cvr/cvx058

Hu J, Geyer A, Dziumbla S, Awwad K, Zeldin DC, Schunck WH, Popp R, Frömel T, Fleming I (2017). Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis. Prostaglandins Other Lipid Mediat 133:93-102. doi: 10.1016/j.prostaglandins.2017.04.002

Ertuna E, Loot AE, Fleming I, Yetik-Anacak G (2017). The role of eNOS on the compensatory regulation of vascular tonus by H2S in mouse carotid arteries. Nitric Oxide 69 :45-50. doi: 10.1016/j.niox.2017.04.007

Juengel E, Krueger G, Rutz J, Nelson K, Werner I, Relja B, Seliger B, Fisslthaler B, Fleming I, Tsaur I, Haferkamp A, Blaheta RA (2017). Correction: Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion. Oncotarget 8 (1):1953-1954. doi: 10.18632/oncotarget.14438

Loroch S, Trabold K, Gambaryan S, Reiß C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U, Jurk K (2017). Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. Thromb Haemost 117 (3):556-569. doi: 10.1160/TH16-07-0515

Randriamboavonjy V, Kyselova A, Elgheznawy A, Zukunft S, Wittig I, Fleming I (2017). Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice. Basic Res Cardiol 112 (1):10. doi: 10.1007/s00395-016-0596-8

Rezende F, Prior KK, Löwe O, Wittig I, Strecker V, Moll F, Helfinger V, Schnütgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schröder K (2017). Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays. Free Radic Biol Med 102 :57-66. doi: 10.1016/j.freeradbiomed.2016.11.019

Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I (2017). AMP-activated protein kinase α2 in neutrophils regulates vascular repair via hypoxia-inducible factor-1α and a network of proteins Aaffecting metabolism and apoptosis. Circ Res 120 (1):99-109. doi: 10.1161/CIRCRESAHA.116.309937

Rukoyatkina N, Subramanian H, Butt E, Nikolaev VO, Mindukshev I, Walter U, Gambaryan S, and Benz PM (2017). Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis. Cell Death & Disease 8:e2898. doi: 10.1038/cddis.2017.290

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ, Brandes RP (2017). Long noncoding RNA MANTIS facilitates endothelial angiogenic function. Circulation 136:65-79. doi: 10.1161/CIRCULATIONAHA.116.026991

Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P, Hassel D (2017). Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. J Mol Cell Cardiol 108:95-105. doi: 10.1016/j.yjmcc.2017.05.011

Siragusa M, Fisslthaler B (2017). Insulin keeps PYK-ing on eNOS: enhanced insulin receptor signaling induces endothelial dysfunction. Circ Res 120:748-50.

Fleming I, Meens MJ, Kwak BR. The endothelial cell. In: Krams R, Bäck M, eds. (2017). The ESC Textbook of Vascular Biology. Oxford University Press p. 73-90. doi: 10.1161/CIRCRESAHA.117.310576


2016

Fleming I (2016). Annexing AXL: Endothelial Cell Infection by the Zika Virus. Circ Res 119 (11):1149-1150. doi: 10.1161/CIRCRESAHA.116.310001

Benz PM, Fleming I (2016). Can erythrocytes release biologically active NO?. Cell Commun Signal 14 (1):22. doi: 10.1186/s12964-016-0145-y

Ziegler N, Awwad K, Fisslthaler B, Reis M, Devraj K, Corada M, Minardi SP, Dejana E, Plate KH, Fleming I, Liebner S (2016). β-catenin is required for endothelial Cyp1b1 regulation influencing metabolic barrier function. J Neurosci 36 (34):8921-35. doi: 10.1523/JNEUROSCI.0148-16.2016

Jung M, Ören B, Mora J, Mertens C, Dziumbla S, Popp R, Weigert A, Grossmann N, Fleming I, Brüne B (2016). Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. Sci Signal 9 (434):ra64. doi: 10.1126/scisignal.aaf3241

Siragusa M, Fleming I (2016). The eNOS signalosome and its link to endothelial dysfunction. Pflugers Arch 468 (7):1125-1137. doi: 10.1007/s00424-016-1839-0

Mangels N, Awwad K, Wettenmann A, Dos Santos LR, Frömel T, Fleming I (2016). The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity. Prostaglandins Other Lipid Mediat 125 :30-9. doi: 10.1016/j.prostaglandins.2016.05.003

Zippel N, Ding Y, Fleming I (2016). A modified aortic ring assay to assess angiogenic potential in vitro. Methods Mol Biol 1430 :205-19. doi: 10.1007/978-1-4939-3628-1_14

McManus S, Tejera N, Awwad K, Vauzour D, Rigby N, Fleming I, Cassidy A, Minihane AM (2016). Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men. J Lipid Res 57 (9):1720-7. doi: 10.1194/jlr.M067801

Shi L, Kojonazarov B, Elgheznawy A, Popp R, Dahal BK, Böhm M, Pullamsetti SS, Ghofrani HA, Gödecke A, Jungmann A, Katus HA, Müller OJ, Schermuly RT, Fisslthaler B, Seeger W, Fleming I (2016). miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach. Cardiovasc Res 111 (3):184-93. doi: 10.1093/cvr/cvw065

Fleming, I (2016). The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling. Vascul Pharmacol 86 :31-40. doi: 10.1016/j.vph.2016.03.001

Juengel E, Krueger G, Rutz J, Nelson K, Werner I, Relja B, Seliger B, Fisslthaler B, Fleming I, Tsaur, I, Haferkamp, A, Blaheta, RA (2016). Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion. Oncotarget 7 (15):20410-24. doi: 10.18632/oncotarget.7804

Snodgrass RG, Boß M, Zezina E, Weigert A, Dehne N, Fleming I, Brüne B, Namgaladze D (2016). Hypoxia potentiates palmitate-induced pro-inflammatory activation of primary human macrophages. J Biol Chem 291 (1):413-24. doi: 10.1074/jbc.M115.686709

Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi, K, Fleming I, Liedtke WB, Kuppe H, Kuebler WM (2016). Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol 54 (3):370-83. doi: 10.1165/rcmb.2014-0225OC

Rezende F, Löwe O, Helfinger V, Prior KK, Walter M, Zukunft S, Fleming I, Weissmann N, Brandes RP, Schröder K (2016). Unchanged NADPH oxidase activity in Nox1-Nox2-Nox4 triple knockout mice: what do NADPH-stimulated chemiluminescence assays really detect?. Antioxid Redox Signal 24 (7):392-9. doi: 10.1089/ars.2015.6314

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